Uncapped wing Jaco Williams, lock Ruben van Heerden and prop Carlu Sadie also start at Kings Park as coach Rassie Erasmus gives a run to every player in his expanded squad across the three Nations Championship matches in July.
Wing Kurt-Lee Arendse returns to the side and fullback Aphelele Fassi completes the back three with debutant Williams, while scrumhalf Cobus Reinach partners Moyo in the half-back pairing.
Pieter-Steph du Toit moves from lock to flanker and will again captain the side, with Jasper Wiese back at number eight and Paul de Villiers retaining his place in the loose trio. Malcolm Marx is back at hooker with props Sadie and Gerhard Steenekamp either side of him as Erasmus opts for a 5-3 split between forwards and backs on the bench.
“We told the players from the start of the season that if everything played out well, we would give everyone in the squad a chance to play in the competition, and we are excited to see what the uncapped players, as well as those who have not been in the mix for a while, bring to the team,” said Erasmus.
“This squad shows an exciting mix of youth and experience, and while we are under no illusions about the threat Wales poses, we are looking forward to seeing what these players can do.
“Wales put up a good fight in their Six Nations matches against Scotland and Ireland, and they defeated Italy in their final match of the tournament. They also beat Fiji in the Nations Championship before going down against Argentina in a competitive match last week, so they are on the rise and will come out with a point to prove this weekend.”
South Africa have taken a full haul of 10 points from their opening two home games against England and Scotland and lead the Southern Hemisphere table.
Team: 15-Aphelele Fassi, 14-Jaco Williams, 13-Jesse Kriel, 12-Damian de Allende, 11-Kurt-Lee Arendse, 10-Vusi Moyo, 9-Cobus Reinach, 8-Jasper Wiese, 7-Pieter-Steph du Toit (captain), 6-Paul de Villiers, 5-Ruben van Heerden, 4-Cobus Wiese, 3-Carlu Sadie, 2-Malcolm Marx, 1-Gerhard Steenekamp.
Replacements: 16-Andre-Hugo Venter, 17-Jan-Hendrik Wessels, 18-Wilco Louw, 19-Ben-Jason Dixon, 20-Marco van Staden, 21-Herschel Jantjies, 22-Manie Libbok, 23-Damian Willemse.