Ravens superstar Jackson set the overall pace with 44,681 votes followed by teammate Derrick Henry in second overall at 40,729 votes.
Philadelphia Eagles running back Saquon Barkley was third overall at 40,602, only 127 votes behind Henry, with Buffalo quarterback Josh Allen fourth overall stacking up 36,574 votes and Detroit running back Jahmyr Gibbs fifth with 35,637.
The Detroit Lions lead all clubs in total votes received, followed by the Ravens, the two-time defending Super Bowl champion Kansas City Chiefs, the Minnesota Vikings and the Pittsburgh Steelers.
The NFL's revamped all-star event will be staged in Orlando, Florida, for the second consecutive year. In all, 88 players will gather on February 2nd in skills competitions and a flag football showdown with coaches Peyton and Eli Manning.
While other vote totals were not revealed, Washington rookie Jayden Daniels was the top NFC quarterback in the fan voting and the top receivers were Minnesota's Justin Jefferson in the NFC and Cincinnati's Ja'Marr Chase in the AFC.
NFL fans can vote as often as they wish through December 23 with selections decided by a consensus of ballots by players, coaches and fans with each group counting for one-third of every player's final total.
NFL players and coaches will cast votes on December 27th.