A fired-up Timberwolves line-up, who had been stunned by the Warriors in game one on Tuesday, were always in control as they powered to a 117-93 victory in Minneapolis that squares the series at 1-1.
Julius Randle led the scoring for Minnesota with 24 points, 11 assists, and seven rebounds while Anthony Edwards finished with 20 points and nine rebounds.
Nickeil Alexander-Walker added an eye-catching 20 points off the bench, including four three-pointers, on a night when five Timberwolves players finished in double figures.
Jonathan Kuminga led the Warriors in scoring with 18 points from the bench, Jimmy Butler finishing with 17.
Edwards said an improved defensive effort led to Minnesota's win after a dismal offensive display in their game one loss.
"We watched film yesterday and we saw it wasn't just that we didn't make our shots - it was more so our defensive effort and intensity. We didn't bring it," Edwards said.
"So we knew we had to bring it today."
With Golden State taking to the floor without Curry, who suffered a hamstring injury in game one, Minnesota set the tone early in the first quarter, racing into a hefty 25-7 lead that left the Warriors chasing the game.
Minnesota were given a scare when Edwards limped off with an ankle problem in the second quarter, but the Timberwolves went into half-time with a commanding 56-39 lead.
Edwards returned for the start of the third quarter, but Minnesota were rocked by an early Golden State onslaught.
Butler and Kuminga both grabbed eight points apiece in a rally that helped the Warriors slash the Timberwolves' lead to just seven points at 62-55 with just under seven minutes remaining in the third.
The Timberwolves regrouped impressively and closed the quarter with a 20-5 run to build an 85-65 lead heading into the final frame.
Without the deadly three-point scoring threat of Curry, the Warriors never looked like closing the gap, and Golden State coach Steve Kerr ran up the white flag with four minutes remaining, removing his starters as Minnesota coasted home.
Game three in the best-of-seven series takes place in San Francisco on Saturday, May 10th.