Centre back Upamecano and Rabiot, who suffer from a cold, are on light training indoors, the French federation (FFF) said.
Upamecano had already missed Monday's training session.
Should they be ruled out, Ibrahima Konate (23) would start at centre back while Youssouf Fofana (23) would be expected to be alongside Antoine Griezmann (31) and Aurelien Tchouameni (22) in midfield.