Coach Eddie Jones’ Japan famously beat South Africa 34-32 in what was dubbed the ‘Miracle of Brighton’, though the Springboks exacted revenge by knocking the Asian side out of their own World Cup on their way to lifting the trophy in 2019.
"The game in Brighton 10 years ago changed rugby in Japan from being a minor sport to a boom sport," Jones, now back in charge of Japan, said. "Playing against the Boks is the dream of every young Japanese player."
The Springboks also face France in Paris the following week before travelling to Italy (November 15), Ireland (November 22) and Wales (November 29) on an unprecedented five-match tour.
South Africa also meet Argentina at Twickenham in their final game of this year's Rugby Championship on October 4.