The Egyptian star registered a goal and an assist as the Reds overturned their deficit to book a quarter-final showdown with Paris Saint-Germain.
After seeing a first-half penalty saved by Ugurcan Cakır, Salah bounced back to score Liverpool’s fourth just after the hour mark.
That strike saw him become the first African player to reach 50 goals in Champions League history.
Forty-seven of his goals in the tournament (excluding qualifiers) have been for the Reds, alongside one and two for previous clubs Roma and Basel respectively.
It was a landmark night at Anfield for another reason too, as Salah recorded his 200th and 201st goal involvements for the club - 140 goals and 61 assists - in just 211 appearances.
Despite an impressive display, he was replaced by Cody Gakpo in the 74th minute as a precaution following an injury scare.
Liverpool’s manager was full of praise for the former African Player of the Year after his standout performance against the Turkish Super Lig side.
"It says a lot about him that after missing a penalty just before half-time (to score that goal)," said Slot.
"That can sometimes be hard for an individual or for a team, so compliment to the team for how we came out in the second half because we've had a lot of setbacks this season. We've had a lot of first or second halves where we've created chance after chance after chance without doing justice to how we've performed, so not scoring.
"Then, Mo and the team came out in the second half the way they did. He assisted first to Hugo, a great assist, and then scored a trademark goal, which he scored many of in this stadium and for this club, coming inside and finding the top corner.
"That tells you about the mental strength of him, but definitely also of the team, because adversity is something we can talk about when it comes to this season."
Barring any serious injury, Salah is expected to lead Liverpool’s attack when they face Brighton in Saturday’s Premier League clash.
