The Gunners hold a four-point lead over Bournemouth, who travel to Manchester City, before their trip to Burnley.
Third-placed Tottenham are only five points off the top but are aiming to end a three-game winless run at home when they host London rivals Chelsea.
AFP Sports looks at three of the key fixtures of the weekend:
Slot feels the heat
Liverpool boss Arne Slot badly needs his star names to get back on track after being dumped out the League Cup by Crystal Palace on Wednesday to compound a miserable run for the Premier League champions.
Slot made his priorities clear by making 10 changes as Palace cruised to a 3-0 win at Anfield against a youthful Liverpool selection.
The Dutchman said he could not risk any more injuries to his key players with the visit of Villa quickly followed by clashes against Real Madrid and Manchester City.
"I don't think it is possible if you lose six out of seven that there is even more pressure," said Slot. "If you are on a run of results like this, if you play for Liverpool, if you manage Liverpool, you know the pressure is there."
Five games into the Premier League campaign, Liverpool led Villa by 12 points. Four matches later they meet separated only by goal difference.
Villa have overcome their difficult start with four consecutive wins, including notable scalps against Tottenham and City, to surge back into contention for the Champions League places.
At the same time, Liverpool's title defence has imploded.
The Reds have not kept a clean sheet for 10 games as Slot struggles to find the right balance to a side disrupted by a huge squad turnover during the transfer window.
Liverpool spent a Premier League record near £450 million, but crucially lost more players than they recruited with Trent Alexander-Arnold and Luis Diaz particularly missed.
"To see the champions lose four games in a row in the Premier League with the expenditure in the summer, I think we're in crisis time for Liverpool right now," said former Liverpool defender Jamie Carragher.
Bournemouth's unbeaten run on the line
The league's longest unbeaten run faces a stern test on Sunday when Bournemouth visit the Etihad, hoping to land another blow to City's title challenge.
The Cherries have not lost since the opening night of the campaign at Liverpool to spark ambitions of qualifying for Europe for the first time in the club's history.
City are six points adrift of Arsenal after a 1-0 defeat at Villa last weekend ended their nine-game unbeaten run.
Pep Guardiola's fear that his side were becoming too reliant on Erling Haaland was realised.
No City player other than the Norwegian has scored more than once in the Premier League this season.
Omar Marmoush and Rayan Cherki have missed much of the opening few months of the season through injury, but both scored in a 3-1 League Cup win over Swansea in midweek to bolster the firepower at Guardiola's disposal.
Spurs seek home comforts
Thomas Frank has made a fine start to solving Tottenham's troubles on the road, but is yet to foster the "fortress" he desires at home.
Of Spurs' 17 points from nine games, 13 have come away from home thanks to impressive wins at Manchester City, West Ham, Leeds and Everton.
But Bournemouth and Villa have won in north London either side of a disappointing 1-1 draw against bottom-of-the-table Wolves.
"We would like our home to be a fortress," said Frank. "It cannot only be the team, it cannot only be the fans. It needs to be both.
"We need to bring energy to each other. We need to work unbelievably hard, perform well, try to be positive."
Only a second league win over Chelsea since 2018 would quickly win over any doubters the Dane faces in the Spurs support.