Indiana will take on No. 5 Oregon, who handed No. 4 Texas Tech their first shutout loss since 2021 (highlights here).
The Hoosiers broke a 0-6 losing streak by teams with a first-round bye in the CFP as their perfect season continues.
First half
It was all Indiana on Thursday. They would outgain Alabama 179-93 in the first half alone, while holding them to just five first downs and forcing a fumble.
After punting on their first drive, Indiana would score on three of their next four. The first came from kicker Nico Radicic, who nailed a 31-yarder to cap off a 16-play, 84-yard drive.
Heisman-winning quarterback Fernando Mendoza would find wide receiver Charlie Becker for a 21-yard touchdown pass on their next drive to go up 10-0.
Both teams would exchange punts before Indiana caused Alabama quarterback Ty Simpson to fumble after scrambling for a first down, making it his sixth lost fumble of the season.
Indiana would take advantage of their opportunity shortly after to extend their lead even further.
Indiana would drive down the field again, this time finishing a 58-yard, 11-play drive with a one-yard touchdown pass from Mendoza to receiver Omar Cooper Jr. with 3:04 left in the second quarter to make it 17-0.
It would mark 11 multi-touchdown games out of 14 this season for Mendoza.
The Heisman winner would finish the game going 14-of-16 passing with 208 total yards and three touchdowns.
Second half
Indiana would force the Crimson Tide to punt on their first drive of the second half, responding with yet another touchdown to go up 24-0.
Mendoza would post his third touchdown of the game after throwing a 24-yarder to Elijah Sarratt down the sideline.
Bama would string together three points with a 28-yard field goal from Conor Talty in the third quarter, but that's where it stopped for the Crimson Tide.
The Hoosiers would score again on the next drive with a 25-yard touchdown from running back Kaelon Black, who'd finish the game with 99 yards on 15 carries.
During Alabama's next drive, they were pushed back for -10 yards in a three-and-out series.
Indiana would unload another touchdown, this time from their other running back, Roman Hemby, for 18 yards.
Hemby finished 89 yards on 18 carries.
In the end, Indiana not only outscored Alabama by a wide margin, but they also outgained them 407-193, putting up 22 first downs to Bama's 11.
Not a single Bama running back rushed for over 20 yards, while Indiana as a team put up 215 on the ground.